Association of Psychological Disorders with Extra-intestinal Symptoms in Patients with Irritable Bowel Syndrome

Irritable bowel syndrome Anxiety Depression Psychological Comorbidity Quality of life

Authors

  • Leila Mirbagher Medical Student's Research Center, Isfahan University of Medical Sciences, Isfahan, Iran, Iran, Islamic Republic of
  • Ali Gholamrezaei
    ali.gholamrezaei@ymail.com
    Medical Student's Research Center, Isfahan University of Medical Sciences AND Poursina Hakim Research Institution, Isfahan, Iran, Iran, Islamic Republic of
  • Farnaz Torkzadeh Medical Student's Research Center, Isfahan University of Medical Sciences, Isfahan, Iran, Iran, Islamic Republic of
  • Manizheh Danesh Medical Student's Research Center, Isfahan University of Medical Sciences, Isfahan, Iran, Iran, Islamic Republic of
  • Hamed Daghaghzadeh Associate Professor, Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran, Iran, Islamic Republic of
  • Sara Kheiri Medical Student's Research Center, Isfahan University of Medical Sciences, Isfahan, Iran, Iran, Islamic Republic of
  • Mohammad Hassan Emami Poursina Hakim Research Institution, Isfahan, Iran, Iran, Islamic Republic of
VOL 2, NO 1 (2015)
Quantitative Study(ies)
March 19, 2015

Downloads

present study, we determined the relationship between psychological disorders and extraintestinal symptoms in patients with IBS.

Methods: Adult patients with IBS referred to 4 gastroenterology clinics in Isfahan, Iran, completed the irritable bowel severity scoring system (IBSSS), extraintestinal symptoms scale, Hospital Anxiety and Depression Scale, and Irritable Bowel SyndromeQuality of Life (IBS-QOL) Questionnaire. Univariate and multivariate analyses were conducted.

Results: The patients included 113 females and 45 males with mean age of 34.8 ± 11.1 years. Cumulative frequency of extraintestinal symptoms was 3.3 ± 2.4 (0 to 10). Anxiety and depression were present in 79.7% and 54.4% of the patients, respectively. Frequency of extraintestinal symptoms was correlated with anxiety and depression (r = 0.289 to 0.531), IBS severity (r = 0.373 to 0.505), and quality of life (r = -0.317 to -0.398). Severity of IBS was independently associated with extraintestinal digestive symptoms' frequency (β = 0.248). Female gender, education level, and anxiety were independently associated with extraintestinal non-digestive symptoms' frequency (β= -0.225 to 0.260). Severity of IBS and frequency of non-digestive symptoms were independent predictors of quality of life (β = -0.494 and -0.218). After controlling for psychological factors, IBS severity and depression were independent predictors of quality of life (β = -0.435 and -0.318).

Conclusion: Extraintestinal symptoms and psychological disorders are common in patients with IBS and impact their quality of life. Psychological disorders are associated with extraintestinal symptoms, especially non-digestive symptoms. These results highlight the need for an integrated biopsychosocial approach to the management of IBS patients with physical and mental comorbidities.

Most read articles by the same author(s)